The incident was reported near West 33rd Street and 7th Avenue around 6 p.m.
The victim approached MTA police after being stabbed.
MTA police requested an ambulance and transferred him to Bellevue Hospital, where he was later pronounced dead.
The MTA said the incident occurred on the street and not in the transit system.
Police say it appears the victim was homeless. He has not yet been identified.
The investigation is ongoing and no arrests have been made.
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